Scientist I/Scientist II, Pharmacometrics

Wave Life Sciences

Wave Life Sciences

Lexington, MA, USA
Posted on Tuesday, April 11, 2023

Job Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.


Wave Life Sciences is seeking a creative, resourceful, and motivated pharmacometrician to join our organization to assist with and/or lead study design and data analysis for programs at various stages. In this role, you will support programs in the discovery, preclinical, and/or clinical stages spanning multiple modalities including RNA editing, splicing and silencing, as well as several disease areas. Strong communication skills and ability to work cross-functionally in a dynamic, fast-paced environment are required. This position is hybrid, you will be expected to work on site at our Lexington, MA facility.


  • Ph.D./M.S. in clinical pharmacology, pharmacokinetics and metabolism, pharmacometrics, chemical/biomedical engineering, computational biology/chemistry or a related field with 0-5 years' pharmaceutical industry /academic experience.
  • Proficiency in common pharmacometrics software, such as Phoenix WinNonlin/NLME, NONMEM, MONOLIX, WinBUGS, STAN, Matlab, R or S+.


  • Applies scientific knowledge and experience to cover a breadth of areas including the design, execution, and analysis and interpretation of pre-clinical and clinical PK and PK/PD studies.
  • Applies quantitative skills to support model-based drug development and address complex issues via modeling and simulation.
  • Interacts with CRO’s and consultants to oversee outsourced activities.
  • Authors reports and regulatory documents.
  • Supports publication strategy
  • Contributes to department infra-structure building and hiring

Key Skills:

  • Demonstrates a sound knowledge of DMPK and PK/PD principles, and possess strong modeling and simulation skills
  • Ability to innovate and think creatively to support development activities and drug development process.
  • Effective communication and interpersonal skills.
  • Strong presentation skills; adept at presentation of clear and accurate reports for internal and external projects
  • Collaborative and self-motivated team player,

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences.