Director/Senior Director, Chemical Biology
Voyager Therapeutics
About Voyager Therapeutics
Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; Neurocrine Biosciences, Inc.; and Sangamo Therapeutics, Inc. For more information, visit www.voyagertherapeutics.com.
Voyager Therapeutics® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc.
Job Summary
Voyager Therapeutics, a leader in AAV delivery technology, is expanding our strategic focus on non-viral delivery to further enhance our position as pioneers in neurogenetic medicine. We are seeking a Director/Sr Director of Chemical Biology with deep expertise in developing targeted delivery technologies for non-viral therapeutics, including biologics and oligonucleotide-based therapeutics, to complement our existing platform technologies. As a Director of Chemical Biology, you will play a crucial role in the research and development of existing and future products. You will be responsible for overseeing all aspects of discovery, bioconjugation, biochemistry and characterization of peptide-based therapeutics for delivery across the Blood-Brain Barrier.
Reporting to the VP of Vector Engineering, you will manage and mentor a high caliber team of scientist and researchers while continuing to grow the group. In addition, you will manage and lead teams and projects in a matrixed environment and interface with a multidisciplinary group of individuals.
Responsibilities
- Leverage vast knowledge in peptide chemistry, oligonucleotide chemistry and conjugation chemistry to discover, engineer or improve performance of existing and future compounds
- Manage a high-performance group of scientists and researchers
- Manage and lead projects in a matrixed environment
- Ability to mentor, retain and recruit top talent
- Provide strategic direction and leadership in all areas of chemical biology
Requirements
- PhD in chemistry, biochemistry, chemical biology, or a related field with at least 10 years of industry experience
- Demonstrated leadership and management experience with a track record of leading teams and projects to successful endpoints and commercialization
- Experience with bioconjugation of enzymes and oligonucleotides
- Deep experience with peptide and protein chemistry with emphasis on optimization of in vivo properties
- Experience in developing nucleic acid-based therapeutics
- Experience in CNS delivery strongly preferred
- Ability to build and maintain collaborations with industry and academic partners
- Expertise in intellectual property protection and expansion
- Familiarity with in vitro and/or in vivo screening methods
- Strong collaboration and stakeholder management skills