Scientist I/II, Novel Capsid Discovery - AAV Payload Engineering

Voyager Therapeutics

Voyager Therapeutics

Cambridge, MA, USA
Posted on Friday, May 26, 2023

About Voyager

Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging innovative expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager’s TRACER AAV capsid discovery platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis and Neurocrine Biosciences as well as multiple programs in Voyager’s own pipeline. Voyager’s pipeline includes preclinical programs in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS), each with validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit

Job overview: In addition to our efforts in the development of designer AAV capsids with tailored properties, we are expanding our payload optimization efforts. We are looking for a talented and motivated Scientist I/Scientist II to join the Gene Therapy team in order to expand our transgene engineering. This will involve optimization and screening of cell- and tissue-specific enhancer and promoter elements, mitigation of vector immunogenicity, regulatable expression systems and more cutting-edge approaches.


  • Validate experimental approaches to characterize the cellular tropism of regulatory sequence via high-throughput tissue analysis
  • Collaborate with computational scientists to identify novel candidate regulatory sequences from large scRNA-seq, ATAC-seq and ChIP-seq datasets
  • Design and implement multiplexed assays to rank and characterize novel tissue-specific enhancers
  • Analyze the effect of viral genome modifications on vector genome stability and potency
  • Collaborate with a diverse team of wet-lab and computational scientists

Required qualifications

  • PhD in biology, biochemistry, biomedical engineering, or a related field
  • 5+ years hands-on wet lab experience
  • Proficiency in cloning design and techniques
  • Expertise in cell culture and aseptic techniques
  • Experience in tissue handling and DNA/RNA purification
  • Experience in quantitative assays (RT-PCR, ddPCR, reporter gene assays)
  • Strong collaborative, organizational, and presentation skills
  • Ability to document, maintain, and share an organized account of lab work and results

Preferred qualifications

  • Experience with flow cytometry and cell-sorting
  • Experience with animal tissues
  • Experience with AAV vectors and library generation/screening