Sr. Associate Scientist, Upstream Development for Protein Development and Manufacturing



San Carlos, CA, USA
Posted on Wednesday, April 10, 2024
Join our Mission to Protect Humankind!
Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.
WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Vaxcyte is looking for an energetic and talented individual to join Vaxcyte’s Vaccine Product Development organization as a Senior Associate Scientist of Upstream Development within the Protein Development and Clinical Manufacturing group. This is an exciting opportunity to join a team to establish a new fermentation development lab and pilot plant at Vaxcyte. The successful candidate will have the following skills and qualities:
· Experience in executing primary recovery experiments at bench-top and/or pilot scale.
· A passionate researcher with a knack for technology innovation to improve performance and efficiency.
· An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals.
· Strong organizational skills and high level of attention to detail.

Essential Functions:

  • Design and execute primary recovery experiments at the benchtop and pilot scale for reagents to enable cell free protein synthesis.
  • Participate in developing scale-up/down models to support technology transfer and manufacturing activities.
  • Author SOPs (standard operating procedure) to document best practices and participate in upstream database management.
  • Analyze and present data at the project meetings.


  • BS in Chemical Engineering or Chemistry/Biochemistry with 4+ years of relevant Pharma/Biotech industry experience, or MS in Chemical Engineering or Chemistry/ Biochemistry with 2+ years of relevant Pharma/Biotech industry experience.
  • Hands-on experience in primary recovery unit operations such as homogenization, continuous centrifugation, and depth filtration.
  • Experience with fermentation and bioreactor operation a plus.
  • Proficiency in statistical analysis and data visualization techniques.
  • Ability to work under supervision in a fast-paced, cross-functional environment and collaborate effectively with other team members.
  • Eagerness and ability to learn and understand new concepts.
Reports to: Senior Scientist, Upstream Development, Protein Development and Manufacturing
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $107,000 – $123,000
Send resumes to:
Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.