Manufacturing Lead - IgG Production

Twist Bioscience

Twist Bioscience

Portland, OR, USA
Posted on Thursday, May 4, 2023

The Manufacturing Lead will be responsible for the manufacture and analysis of a variety of gene products across Twist Bioscience’s proprietary process workflow to meet the Twist production forecast and timelines.

The Manufacturing Lead will be held accountable for maintaining production schedule and troubleshooting, guiding the work of other shift associates while also performing manufacturing tasks. Activities will include but not be limited to: operating a variety of laboratory equipment including liquid handling robots, maintaining detailed documentation, cleaning and restocking the lab, and practicing good lab bench techniques to ensure high quality and consistent products.

The ideal candidate will be driven and will do what it takes to keep manufacturing on track in a fast paced start-up environment. The Manufacturing Lead will also be responsible for the production of genes and various intermediates according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule.

What You’ll Be Doing

  • Assisting the production supervisor and guiding the work performed on the manufacturing floor by manufacturing associates.
  • Troubleshooting all processes related to manufacturing process and instrumentation.
  • Taking responsibility for daily operations when the supervisor is not available.
  • Maintaining daily operations w/ or w/o the supervisor (equipment maintenance, fulfill production request, retain review)
  • Reviewing time sensitive material and calendar events.
  • Overseeing material inventory and waste management activities for the shift.
  • Monitoring the flow of intermediate products through the Manufacturing Execution System (MES) and notifying the supervisor of any discrepancies.
  • Reviewing JIRA tickets with supervisor to create action items.
  • Enforcing checklist and auditing activities which are built into the production process.
  • Training new laboratory manufacturing associates.
  • Working in the laboratory and performing any process tasks.
  • Manufacture high quality custom oligo containing products in a high throughput MFG lab according to established SOPs.
  • Operate laboratory equipment and liquid handling robots (Hamilton Stars, centrifuges, sealers, thermocyclers, spectrometers, Illumina Next-Gen sequencers etc.)
  • Effectively use molecular and cell biology processes and techniques, especially PCR, DNA quantitation, purification and cloning.
  • Maintain thorough, accurate and detailed documentation of all work performed using existing document templates and applications.
  • Update and write work instructions and documentation.
  • Work independently and in a safe manner.
  • Pay great attention to details and yield consistent results.
  • Perform troubleshooting and handle process deviations correctly.
  • Analyze data outcome from manufacturing steps and decide on or recommend a course of action.
  • Follow lean manufacturing, ISO and GMP practices.

What You’ll Bring to the Team

  • Bachelors/Associates degree in biology, chemistry, biochemistry: degree preferred but will consider candidates with relevant laboratory experience
  • Familiarity or prior experience in a manufacturing environment
  • Good written and verbal skills
  • Attention to details
  • Good computer skills and comfort in using computers for all aspects of MFG, experience with excel and word, Jira/Confluence, web based or similar programs

Physical Requirements

  • Working in controlled laboratory environment
  • Must be able to stand for long periods of time while performing duties
  • Must be able to work safely with chemicals and hazardous materials
  • Must be able to lift up to 20 lbs
  • Must be able to work outside of regular work hours/ work a flexible shift as needed

Possible Shifts:

SHIFT 1A: Sunday-Wednesday / Sunday-Tuesday 7AM-7PM 12h day/ 3d /4d alt work week with 1 weekend day

SHIFT 1B: Wednesday-Saturday / Thursday-Saturday 7AM-7:30PM 12h day/ 3d /4d alt work week with 1 weekend day

SHIFT 2A: Sunday-Wednesday / Sunday-Tuesday 7PM-7:30AM 12h day/ 3d /4d alt work week with 1 weekend day

SHIFT 2B: Wednesday-Saturday / Thursday-Saturday 7PM-7:30AM 12h day/ 3d /4d alt work week with 1 weekend day

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.