VP, Manufacturing Technology & Supply

Orchard Therapeutics

Orchard Therapeutics

London, UK
Posted on Thursday, April 25, 2024

Location: London

Reporting to: Chief Technical Officer

Job Summary

Orchard Therapeutics, recently acquired by Kyowa Kirin with the goal of accelerating the delivery of new gene therapies to patients around the globe, is looking for a dynamic and experienced Vice President of Manufacturing Technology and Supply. Reporting to the Chief Technical Officer, the role will provide strategic leadership and oversight of all internal and external manufacturing operations as well as global supply chain activities, including the planning and execution of global expansion into new markets, to achieve on-time delivery of high-quality products to patients in the most efficient and cost-effective way.

The incumbent will lead the team to successful completion of strategic and pipeline projects through effective project management and identification and escalation of risks. Assigned projects may include technical transfer (analytical/process), execution of regulatory strategies and commitments, process validation, operational efficiency, capacity planning, and distribution. In addition, this person will own and drive program risk management and be accountable for budgetary planning and control.

Success in the role will require effective collaboration with all internal functions, particularly Technical Development, Quality and CMC Regulatory and externally with our CDMOs and partners.


  • Provide strong leadership, set the vision, and architect the path to delivering rapid, flawless, compliant and cost-effective delivery of consistently high-quality products
  • Create world-class, state-of-the-art, cell and gene therapy MSAT and supply chain processes, and associated IT infrastructure. Actively engage in external benchmarking to maintain competitive advantage.
  • Build and develop a highly performing manufacturing and supply chain team that is focused on excellence and continuous improvement
  • Implement and execute upon the manufacturing technology roadmap
  • As the head of the function, provide leadership and direction, lead critical milestone reviews, decision making, issue resolution, risk mitigation and continuous improvement of processes to ensure commitments are met
  • Effectively communicate with team members, and key stakeholders on the status, objectives, risks, and mitigation plans associated with projects, mentor and coach the team
  • Build strong collaborative relationships with internal and external stakeholders to ensure effective and reliable demand forecasting and supply planning that ensures adequate manufacturing capacity and adequate product and raw material inventory availability at the right time
  • Work closely to support GMP and non-GMP production activities and product distribution activities and support functional areas during long range planning / budget planning
  • Assist in the creation and deployment of standards around project and workload management to improve efficiency, expand functional capabilities and streamline use of resources
  • Ensure that department objectives are in line with company objectives and be fully accountable to achieve goals, strategic directives and ensure that targeted project milestones are met within agreed upon timelines
  • Serve as a role model to foster a culture of high performance and trust