Scientist I, Biophysics - Drug Discovery Technology

Nurix Therapeutics

Nurix Therapeutics

San Francisco, CA, USA
Posted on Wednesday, October 11, 2023


We are seeking a talented scientist with a strong background in Biophysics to join our Drug Discovery Technology Department. In this laboratory-based position, you will be part of a diverse team that is focused on advancing projects by collecting and interpreting biophysical assay data for ongoing discovery programs, hit identification, and hit to lead efforts. You also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to project teams and senior management. The successful candidate will have the opportunity to directly contribute in the following areas:

  • Plan and execute small molecule-protein biophysical assays to characterize binding affinity and kinetics
  • Identify novel chemical matter using biophysical screening techniques of extensive small molecule compound libraries
  • Characterize the binding affinity and kinetics of binary and tertiary complexes of proteins and targeted protein degrader molecules
  • Characterize the binding of small molecule-DNA conjugate molecules from DNA-encoded library (DEL) screening campaigns
  • Evaluate new technologies and develop novel biophysical assays
  • Engage in cross-functional team discussions that support our DEL screening groups, internal project teams, collaboration projects, and machine learning efforts
  • Find opportunities for platform automation and propose method improvements to realize gains in experimental efficiency
  • Prepare reports and present data at internal group meetings

Education and Experience

  • Ph.D. in Biophysics, Biochemistry, or related discipline with up to 3 years relevant experience OR MS with 5 years relevant experience, OR BS or equivalent with 10 years relevant experience
  • Experience using biophysical techniques to analyze protein-small molecule interactions
  • Extensive, hands-on laboratory experience in the use of Surface Plasmon Resonance biosensors (SPR) or Grating-Coupled Interferometers (GCI)
  • Expertise in the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
  • Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
  • Excellent communication skills and ability to present scientific rationale, key data, issues and accomplishments to other scientific colleagues

Added Quantifications

  • Experience working in PROTAC-based drug discovery programs
  • Experience working with molecular biology tools (PCR, qPCR, Western Blot)
  • Good fit with Nurix culture

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

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