Scientist I, DNA Encoded Library Technology - Discovery Chemistry

Nurix Therapeutics

Nurix Therapeutics

San Francisco, CA, USA
Posted on Saturday, July 29, 2023


We are seeking a talented and highly motivated chemist with a strong background in DNA-encoded library (DEL) synthesis to join our Discovery Chemistry team. In this laboratory-based position, you will be part of a highly versatile team that is focused on advancing projects though Nurix’s on-DNA to off-DNA lead discovery platform. The successful candidate will have the opportunity to directly contribute to the following key platform operations:

  • Plan and execute on-DNA DEL hit resynthesis campaigns.
  • Design and validate novel DEL library builds.
  • Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
  • Construct DEL libraries to support the in-house library production efforts.
  • Work with external partners to support our DEL synthesis and hit follow up strategies.
  • Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
  • Influence high-throughput platform automation and technology development efforts.
  • Contribute to scientific strategies and group goals focused on discovery stage hit-to-lead identification and optimization.
  • Prepare reports and present data at internal group meetings.

Education and Experience

  • Ph.D. in Medicinal Chemistry with up to 4 years relevant experience OR MS with 6+ years relevant experience, OR BS or equivalent with 10+ years relevant experience.
  • Strong background in synthetic organic chemistry.
  • Hands-on laboratory experience in carrying out on-DNA synthesis and methodology development.
  • Familiar with the overall DNA-Encoded Library Technology workflow operations.
  • Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).
  • Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
  • Established track record of conference presentations and peer-reviewed publications in the areas of Organic Chemistry and DNA-Encoded Library Chemistry

Added Quantifications

  • Postdoctoral or industrial work experience in the DEL field.
  • Experience working in the PROTAC-based drug discovery programs.
  • Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
  • Experience working with molecular biology tools (PCR, qPCR, Western Blot)

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

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