Principal Scientist, Anti-Fungal Drug Discovery

LifeMine Therapeutics

LifeMine Therapeutics

Cambridge, MA, USA
Posted on Friday, December 22, 2023

Job Summary

We are seeking a highly motivated and detail-oriented drug discovery scientist with broad experience in fungal genetics/microbiology and medical mycology to join our growing drug discovery team located in Cambridge, MA. The ideal candidate will have made substantial contributions to the understanding of basic fungal biology and/or translational anti-fungal research including in a drug discovery setting. Expertise in the pathogenesis and treatment landscape for fungal diseases (eg. aspergillosis, candidiasis, or cryptococcus), is a plus.

This position will be based in Cambridge, MA.

Job Responsibilities

  • Design, develop and optimize in vitro assays for screening GEMs against diverse fungal strains with the goal of discovering new drugs for pathogenic fungal infections; plan and execute in vivo studies with CROs/vendors
  • Collaborate with genomics, automation, synthetic biology, and GEM retrieval teams to make the screening workflow robust, automated and high throughput
  • Keep up-to-date with current literature, and ensure broader team is aware and reacts to changes in clinical treatment landscape
  • Play a key role in leading and influencing project team members from multiple functional areas without direct authority
  • Be a hands-on leader in the laboratory setting, including mentoring Scientists and Research Associates and be involved in the design of studies and interpretation of data
  • Generate oral and written reports on performed experiments. Attend team meetings for experimental planning and present results in project team meetings and to leadership

Job Requirements

  • PhD with 6+ years of biotech/pharma experience in Fungal Infection Biology/Genetics or related subject area with hands-on experience in culturing and manipulating fungi; experience in whole animal models for anti-fungal research desired
  • Deep knowledge of biology and pathogenesis of filamentous fungi and secondary metabolism; well versed in designing assays to monitor fungal growth/proliferation as well as pathway biology and mechanism-of-action
  • Ability to translate laboratory research into the translational/clinical setting for patient treatment
  • Good familiarity with Clinical Laboratory Standards Institute (CLSI) assay protocols for anti-fungal testing
  • Excellent written and oral communication skills; ability to influence and lead project team members without direct authority
  • A strong desire to contribute to cutting-edge anti-fungal drug discovery and work collaboratively in a highly dynamic matrixed team environment