Career Opportunities in the Foresite Capital Network

LifeMine Therapeutics is reinventing drug discovery by mining genetically-encoded small molecules (GEMs) from the biosphere. Through our evolutionarily-derived genomic drug discovery platform, Avatar-Rx, LifeMine aims to bring unparalleled speed, predictability, and scalability to drug discovery. LifeMine has discovered, in genomic space, hundreds of potentially high-impact drug candidates relevant to targets across all major disease areas and has an initial focus on advancing highly impactful precision medicines in oncology and immune modulation.

Headquartered in Cambridge, Massachusetts, USA, LifeMine is opening its European Headquarters in Basel. Our 4,000 m2 facility is in Klybeck, Basel, right next to the beautiful Rhine River and the train station, also close to City Center. The Klybeck area is home to many top US and Swiss pharmaceutical and Biotech companies in Europe’s biotechnology hub.

Summary

We are seeking a highly motivated PhD-level scientist skilled in analytical chemistry techniques including mass spectrometry to impact our small molecule drug discovery platform. The primary role of this position will be to identify genetically encoded small molecule leads. The successful candidate will thrive in a fast-paced environment and collaborate within multidisciplinary teams.

Responsibilities

• Design, develop and execute LC-HRMS/MS methods for screening fungal extracts
• Contribute to the identification of fungal metabolites of interest via differential MS technology
• Contribute and expand the GEMs leads workflow.
• Perform independent hands-on experimental work utilizing mass spectrometry, liquid chromatography and other analytical techniques.
• Some development and execution of AP-MS/AS-MS pull-down techniques to support the identification of GEMs leads will be required
• Evaluate and/or develop new technologies and identify proprietary technical opportunities.
• Optimize sample analysis, data interpretation, and effectively communicate to cross functional teams.
• Accurately and timely documentation of experiments and results

Requirements

• PhD in Chemical Biology, Biochemistry, Natural Products Chemistry, Medicinal Chemistry, Analytical Chemistry, Pharmaceutical Sciences or related fields.
• 0-4 years Industry experience in Pharma or Biotech a must.
• Experience applying liquid chromatography and mass spectrometry techniques to small molecules. Protein experience is a plus
• Must have knowledge and experience in LCMS applications, analysis and metabolomics, high resolution TOF, Orbitrap, ion trap MS instruments.
• Experience developing LC-based methods coupled to MS and/or other detection methods
• Strong understanding and familiarity with laboratory methods
• Data recording, interpretation, and documentation skills with attention to detail
• Communicate progress effectively with colleagues and managers
• The successful candidate should be a self-starter, enjoy working in a fast-paced dynamic team environment, and be motivated to develop and apply new technologies to advance projects efficiently.
• The successful candidate should be a self-starter, enjoy working in a fast-paced dynamic team environment, and be motivated to develop and apply new technologies to advance the projects efficiently.