Senior Associate Scientist

Intellia Therapeutics

Intellia Therapeutics

Posted on Monday, May 15, 2023

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

We are looking for a talented Scientist to join Nuclease Engineering Team in Gene Editing Platform Group. You will be working on diverse Protein Engineering projects to advance our gene engineering capabilities that will enable the development of tailored therapies for complex genetic diseases. You will work on various screening methods and validate results using biochemical or cell biological methods. You will also have opportunities to collaborate with stakeholders in Ex Vivo and In Vivo platforms. Additional responsibilities include:

  • Develop and execute high-throughput screening methods to improve proteins of interest with desirable characteristics

  • Utilize biochemical, cell and molecular biology approaches to validate the function of engineered protein

  • Design bacterial, mammalian expression constructs, and be able to deliver various biological payloads using different delivery modalities

  • Design and perform next-generation sequencing experiments

  • Perform comprehensive data analysis and troubleshoot experiments

  • Present scientific findings in team meetings and cross-functional meetings

  • Document experiments in a timely manner using electronic laboratory notebook system

  • Comply with laboratory safety regulations

About You:

You are a highly motivated, goal-driven person, who is genuinely excited about science and not afraid of new challenges. You have deep understanding in protein structure-function relationship, and experience in biochemical, cell-based assays.

  • Ph.D in Biochemistry, Structural Biology or Cell/Molecular Biology with 2+ years of relevant experience, or MS with 5+ years of relevant experience (this can be adjusted depending on SAS or Scientist position)

  • Hands-on experience in rational library design and screening of pooled libraries using bacterial or mammalian systems

  • Hands-on experience in various quantitative and qualitative assays, such as Octet, MSD, enzyme kinetics assay, ELISA

  • Experience with mammalian cell culture, FACS, and cell based assays

  • Ability to do routine molecular biology techniques, such as PCR, NGS, protein expression

  • Comprehensive knowledge in CRISPR-Cas9, computational biology, experience in NGS data analysis

  • Organized, detail-oriented, and demonstrated independent thinker

  • Excellent verbal and written communication, teamwork, and strong problem-solving skills

Meet your future team:

The Gene Editing Platform team is a group of highly motivated and collaborative scientists. This group is responsible for the development of CRISPR-Cas9 based gene editing tools to advance Intellia’s platform to enable curative therapies. As a part of the Platform Innovation function, you will have opportunity to broaden your experience with multiple-cutting edge gene therapy technologies.

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we require the candidate to be currently local to Cambridge MA, or open to relocating. Our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in biotech and chemistry. If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient’s lives.


Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.