Associate Scientist, PreClinical in vitro Pharmacology

Intellia Therapeutics

Intellia Therapeutics

Posted on Monday, May 15, 2023

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

Intellia is looking for an Associate Scientist focused on cell biology and assay development to support the advancement of genome editing products into the clinic. Within this role, you will be responsible for the execution of in vitro pharmacology data packages and the generation of in vitro genotoxicity samples enabling in vivo and cell therapy program progression into clinical trials. You will be responsible for the documentation enabling regulatory filings including data documentation and quality control. In this role you will:

  • Conduct standard cell culture support including cryovial recovery, plating, maintenance and collection of primary and immortalized cell lines

  • Support high throughput, SOP-driven cell plating and dosing workflows both manually and using liquid handling automation

  • Develop appropriate cell-based models and molecular assays to measure on-target editing, target mRNA and/or protein expression level.

  • Work with research teams to transition relevant assays and methods from research into development through optimization to apply to regulatory programs implementing SOPs, standards, qualifications, etc

  • Establish and write SOPs as well as communicate data through presentation and written documentation.

  • Conduct experiments, troubleshoot, and optimize independently and in collaboration with colleagues to meet deadlines.

  • Execute in vitro pharmacology data packages in relevant species cell models.

  • Accurately document project and sample information, protocols, and experimental details through the Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN).

  • Write and QC technical and study reports to support regulatory filings (IND or CTA equivalent)

  • Partner with Project Management and PreClinical Genomics on the execution of in vitro sample preparation in support of genotoxicity assays

About You:

The Scientist PreClinical in vitro pharmacology will have demonstrated expertise in cell biology, assay development, molecular biology, gene editing approaches, and experience in supporting gene editing therapies into the clinic.

  • BS/MS with >5/>2 years of equivalent relevant experience in an academic of industrial setting

  • Solid hands-on experience in cell culture techniques including primary cell culture. Primary hepatocytes is preferred.

  • Assay development, optimization, and qualification experience

  • Strong time management and process-oriented thinking

  • Experience with CRISPR gene editing approaches in cell models

  • Experience with qPCR, MSD and ELISA is a plus

  • Knowledge of NGS is a plus

  • Experience with liquid handling platforms (preferably Hamilton) is preferred.

  • Experience in writing and documentation to support regulatory filings is preferred.

Meet your future team:

The PreClinical team is a fun, energetic, and passionate group of individuals focused on pre-clinical Genomics data support for regulatory packages. You will report directly to the Director of the Pre-clinical in vitro Pharmacology. Given the breadth of work on this team, the candidate will have the opportunity to explore a wide range of areas within the Automation, Engineering, Genomics, Informatics, and Screening (AEGIS) groups.

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we require a candidate to be currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require managing wet-lab work, our team is focused on building not just technical expertise but fostering an environment for the growth of young scientists interested in a career in biotech. If you join our team, you can expect to join a hardworking, collaborative but flexible environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patients' lives. We instill a culture of teamwork, respect, inclusion, collaboration, and communication ensuring that each team member strives to reach their professional and personal potential.


Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.