Associate Scientist II/III, Metabolic Diseases



South San Francisco, CA, USA
Posted on Tuesday, October 24, 2023

The Opportunity

The heart of insitro’s strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are putting together a team of life scientists with expertise in cellular and biochemical assays.

In this role, the successful candidate will be responsible for the development and execution of mid/high throughput biochemical/cellular assays and mechanistic experimentation to advance early stage drug discovery projects. The candidate will work closely with a team of multidisciplinary scientists to enable key assays/models and studies to advance a diverse portfolio of small molecules targeting neurological and metabolic disorders. We value a highly collaborative working style centered on effective communication and rigorous scientific exploration. If you are a highly motivated teammate with a strong desire to impact patients in diseases related to metabolic disorders, we invite you to consider joining our team!

You will be joining a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing opportunities for significant impact. You will work closely with a very dedicated team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

Primary responsibilities:

  • Develop, optimize, and perform cellular assays to support the Metabolic Diseases therapeutic area
  • Culture immortalized, primary (e.g. hepatocytes and adipocytes) and iPSC-derived cells
  • Use molecular biology and functional genomics techniques such as CRISPR and siRNA to evaluate disease biology
  • Conduct imaging-based assays to support the metabolic disease therapeutic area
  • Maintain accurate documentation of experiments in electronic lab notebook (ELN)
  • Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver project goals

About You

  • BS/MS in Biochemistry, Cell Biology, Pharmacology or a relevant scientific subject area, with a minimum of two (2) years of drug discovery experience in a biotech/pharmaceutical setting
  • Experience in the development and execution of cellular assays using a wide range of experimental methods and detection technologies including advanced microscopy, ELISA, immunofluorescence
  • Hands on experience in culturing liver cells and iPSC differentiation, a plus
  • Proven ability to work in cross-functional teams to advance drug discovery, with excellent organization and communication skills
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $90,000 - $115,000. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit