Scientist II, Neuroscience, Translational Medicine (Biomarkers)



South San Francisco, CA, USA
Posted on Friday, August 11, 2023

The Opportunity

The heart of insitro’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and small molecule discovery that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented translational scientists who want to make a difference to this important problem. The Scientist II, Translational Medicine (Biomarkers) will be responsible for supporting biomarker identification development to advance insitro’s non-clinical and clinical development pipeline. Specifically, the candidate will work in a cross-functional, multi-disciplinary environment to understand the biology of therapeutic targets/disease indications to identify and develop relevant biomarkers to inform non-clinical and clinical research strategy, study/trial design, and data analysis/interpretation in the context of neurological disease and disorders. A successful candidate will be flexible, collaborative, innovative, and rigorous and will thrive in a dynamic, exciting, and high-impact environment.

In broader context, you will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

Primary Responsibilities

  • Evaluation therapeutic targets and associated biology
  • Evaluation of disease indications and associated biology and any established biomarkers
  • Evaluation and prioritization of different endpoints/biomarkers that translate from in vivo studies to clinical trials.
  • Monitoring of ongoing internal and external clinical trials, with an emphasis on biomarker utilization, analysis, and interpretation

About You

  • MD, MD/PhD, or PhD with 4+ years of experience in clinical and/or biomarker development
  • Experience with providing a clinical input during non-clinical development and early clinical development to ensure success of regulatory submissions and seamless transition to clinical development
  • Experience as a clinical subject matter expert in a neurological disease or similar
  • Experience in the design, implementation, execution, monitoring, and data analysis and interpretation for clinical trials
  • Experience performing diligence on therapeutic target biology and/or clinical indications

Nice to Have

  • Direct experience with genetic epilepsies, neurodevelopmental disorders, and neurodegenerative diseases
  • Direct experience with regulatory submissions (e.g. pre-IND, IND) particularly with respect to the clinical sections
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $125,000 - $140,000. To determine starting pay, we consider multiple job-related factors including a candidate’s skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit