Senior Bioinformatics Engineer (Remote) #2877



United States · Remote
Posted on Wednesday, March 22, 2023
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit
GRAIL is seeking a Senior Bioinformatics Engineer to join the Bioinformatics and Data Science team. In this role, you will work with Scientists, Bioinformaticians, and Statisticians to develop bioinformatics data processing pipelines and scientific software for processing and analyzing molecular data. This software will be at the core of critical scientific and product development activities including training machine learning classifiers, analyzing experimental results, and processing data as part of GRAIL's diagnostic tests.
The ideal candidate will have a strong computer science background, with a passion for creating well-written, scalable, and robust software for sample processing pipelines in a regulated environment.


  • Coordinate with a cross-functional team to develop new software features, process study samples, support analysis objectives, and lock device software for new products.
  • Design and implement efficient and horizontally-scalable bioinformatics software, in support of research and product initiatives.
  • Maintain a high level of software reliability by adhering to and enforcing sound engineering principles, including thorough testing.
  • Follow the formal development and release procedures needed to convince others of this reliability, meeting the high standards expected of regulated diagnostic devices.
  • Take the initiative to rigorously investigate and fix issues that still fall through the cracks; and pioneer new initiatives that make this come up less often.


  • Engineering, Bioinformatics, Math, or related Master's degree with 5+ years of experience or Ph.D. with 3+ years of experience in a relevant position.
  • Expert knowledge in designing, building, and testing scientific software and data analysis pipelines.
  • Professional software engineering experience, including extensive experience in at least one system-level programming language like Go, Java, or C++.
  • Previous experience working in and developing infrastructure for cloud environments.
  • Moderate familiarity with developing bioinformatics pipelines with a workflow engine, like Reflow or NextFlow.
  • Experience with cross-functional collaborations while ensuring data quality and commitment to analysis reproducibility.
  • Strong communicator who can discuss complex technical concepts with cross-functional collaborators and capture solutions in technical documentation.


  • Working knowledge of common bioinformatic tools for processing next-generation sequencing data.
  • Experience developing software for regulated products.
The estimated, full-time, annual base pay scale for this position is $150,000 - $176,000. Actual base pay will consider skills, experience, and location.
Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.
In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.
GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. GRAIL maintains a drug-free workplace.
Following extensive monitoring, consideration of business implications, and advice from internal and external experts, GRAIL US has made the decision to require that all U.S. employees be “Fully Vaccinated” with the COVID-19 vaccine. “Fully Vaccinated” is defined as two weeks after both doses of a two-dose vaccine (e.g. Pfizer or Moderna) or two weeks since a single-dose vaccine (e.g. Johnson & Johnson) has been administered. Absent a qualifying exemption, all GRAIL US employees are to comply with this requirement, including providing documentation of such vaccination status, as a condition of employment. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation for consideration by GRAIL.