Senior Scientist II, In Vivo Therapeutics Discovery

Editas Medicine

Editas Medicine

Cambridge, MA, USA
Posted on Tuesday, April 23, 2024

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Editas Medicine is seeking a highly motivated and collaborative cell biologist to join our In Vivo Therapeutics Discovery group. In this role, you will support on-going efforts to develop in vivo gene editing therapies and contribute to the evaluation and identification of new targets. You will lead the development and characterization of rodent animal models and molecular and cell-based assays to evaluate the extent and effects of gene editing. The ideal candidate will have a diverse in vitro and in vivo experimental skill set with a strong background in primary cell culture and molecular biology, a track record of creative thinking, and a deep interest in genome editing. The successful candidate will be part of a dynamic, multidisciplinary discovery team dedicated to the development of gene editing-based therapies for major disease indications.

Key Responsibilities & Accountabilities:

  • Serve as subject matter expert and lead early-stage discovery programs through DC nomination.
  • Lead assay development and implementation to demonstrate gene editing and impact on target expression in relevant cells in vitro and target tissues in vivo.
  • Plan and execute mouse experiments to understand in vivo therapeutic activity, efficacy, and PK/PD properties associated with drug candidates.
  • Perform in vitro or ex vivo assays to assess disease phenotype.
  • Contribute to the exploration and identification of new targets and engage with cross-functional stakeholders to determine the probability of technical, clinical, and commercial success.
  • Contribute to timeline, milestones, success criteria, MPP, and TPP development.
  • Generate technical documents, SOPs, study reports and other forms of documentation for IND-enabling activities and procedure development.
  • Suggest and implement changes to IACUC protocols.
  • Synthesize literature, analyze and present data within and outside the organization.
  • Serve as a technical and scientific resource for junior staff.
  • Share responsibility in maintaining lab equipment and reagent inventory.
  • Maintain electronic lab notebook in a timely fashion.
  • Interact with vendors, collaborators, and internal teams for various functions.