Manager, Screening and Sample Management - 2442

Editas Medicine

Editas Medicine

Cambridge, MA, USA
Posted on Tuesday, January 23, 2024

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Position Summary

Editas is seeking a highly motivated Manager for our Platform Technology Group. In this role, you will develop cellular assays, and lead your team to deploy lab automation solutions for research, clinical development, and manufacturing applications. You will work with other scientists and project teams to develop/adapt, scaleup, test and standardize key assays and processes in both research and clinical development, having a direct impact on the newest genomic medical advancements.

In addition, the manager will generate and QC research grade editing reagents and document information in our LIMS system. Reagent orders are requested through our LIMS and JIRA systems, and stakeholders will need to be updated on a weekly basis on the status of the requests.

An ideal candidate should have a strong background in scaling up cellular, biochemical and assays using a wide range of laboratory automation. This includes liquid handling robots, such as the Biomek I7, acoustic liquid transfer, such as the Echo and automated sample storage systems, such as the Hamilton SAM. The candidate will help put together yearly budgets for screening projects and automation.

The position will report to the Sr. Director of Platform Technologies. The individual will be responsible for training and coordinating the execution of screening projects with his/her team of 2 research associates, and he/she will be working with cross-functional teams and external partners. The individual will require creativity and flexibility to develop and build durable automated processes to scale up complex biological systems and work with our Informatics and Computational Biology teams to help implement processes.

Key Responsibilities:

As the Manger of Screening and Sample Management, you will be responsible for:

  • Experienced team lead to apply high throughput technologies to identify, characterize and select CRISPR/CAS9 and Cas12a therapeutic RNP and LNP candidates.
  • Work collaboratively across several therapeutic projects to develop and run cell assay models.
  • Cell models include human and mouse cell lines, primary human T-cells, hematopoietic and other cell types.
  • Managing the generation, QC, LIMS tracking and distribution of research grade editing reagents for internal projects and external partnerships.