Scientist I, Gene Editing and Protein Engineering
Editas Medicine
What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.
At Editas, our mission is to champion belonging, inclusivity, diversity, and equity, cultivating a culture where every individual feels valued and included. This commitment fuels our drive to excel in scientific innovation, allowing us to harness the power of gene editing to develop groundbreaking and life-changing therapies for people living with serious diseases with the greatest unmet needs.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
As the Scientist, Molecular Biology, you will lead a team in pioneering platform technology development, specializing in innovative gene editing technologies. Your role involves designing and implementing in vitro and cell-based systems for high throughput screening, executing directed evolution processes to engineer gene editing technologies, and constructing libraries using rational and combinational methods. With a focus on efficacy and specificity, you'll build assays for novel technologies, while also providing scientific guidance and managing junior team members. This person, having expertise encompassing a range of molecular biology techniques, mammalian cell culture, and protein structure/function studies, will be a key player in advancing groundbreaking scientific endeavors.
Key Responsibilities:
As the Scientist, Molecular Biology, you will be responsible for:
- Lead a small team for innovative platform technology development.
- Develop in vitro or cell-based systems for high throughput screening.
- Design and execute directed evolution processes to engineer gene editing technologies with desired properties, including novel DNA recognition sites, higher sequence-specific activity and specificity.
- Design and construct libraries using rational and combinational methods.
- Build assays to quantify and measure efficacy and specificity of novel technologies in vivo and in vitro.
- Provide training, scientific and personnel management of junior team members.
Required Qualifications:
The ideal candidate will possess:
- Ph.D. in cell biology, molecular biology, bioengineering, or a related field or
- 4+ years of industry experience in molecular biology or a related field
- Molecular biology expertise including plasmid design, molecular cloning techniques such as Gibson assembly and golden gate cloning, primer design, PCR, gel electrophoresis, DNA and RNA purification, qPCR, and RT-qPCR
- Experience in mammalian cell culture, transfections, and cell-based assays
- Extensive experience in protein structure/function study and protein engineering.
- Molecular biology expertise including plasmid design, molecular cloning techniques such as Gibson assembly and golden gate cloning, primer design, PCR, gel electrophoresis, DNA and RNA purification, qPCR, and RT-qPCR
- Experience in mammalian cell culture, transfections, and cell-based assays
- Extensive experience in protein structure/function study and protein engineering.
Preferred Qualifications:
Additionally, candidates with the following attributes are preferred:
If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.
Fostering Belonging. Fueling Innovation. Transforming Lives.
Benefits Summary:
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.