Senior Scientist, Biochemistry (Biotherapeutics)

Denali Therapeutics

Denali Therapeutics

San Francisco, CA, USA
Posted on Tuesday, January 24, 2023

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

The Opportunity:

Denali is continuing to build a leading, innovative Biotherapeutic Discovery organization that will strongly contribute to the discovery and development of novel therapeutics for neurodegenerative diseases. We are currently seeking a talented candidate to join our Protein Sciences team to support Denali’s expanding large molecule biotherapeutics efforts with the goal of identifying novel therapeutics for the treatment of neurodegenerative diseases. This position will primarily be at the bench, and the successful candidate will be expected to independently conceive, initiate, and direct protein production and related technology development efforts, in alignment with the goals of the Biotherapeutic Discovery organization. He/she should have experience in all aspects of protein purification, including chromatographic separation by gravity and liquid chromatography methods, all relevant analytics for the quality assessment of purified protein (which may include intact mass spectrometry, ligand binding assessment by SPR or related methods), and ideally also have experience in biochemical assay development, Accordingly, we seek candidates with demonstrated and documented experience in producing and assessing the purity and activity of complex proteins such as engineered antibodies, Fc-fusions and/or bioconjugated therapeutics.

The successful candidate will be responsible for leading the production of large molecule biotherapeutics from milligram to gram scale, including development of robust and scalable purification processes and fit-for-purpose analytics that support the identification and characterization of novel therapeutics. Close collaboration with protein engineers, pharmacologists, biologists & CMC teams will be essential to success.


  • Develop and troubleshoot protein expression and purification processes for large molecule biotherapeutics.
  • Evaluate and establish technologies to enhance and/or advance protein production and characterization, including high-throughput approaches, in support of Discovery projects, platforms, and pathways.
  • Develop and perform protein purification, biophysical and biochemical characterizations. In this capacity, support and meet timelines for production of a wide variety of proteins, including antibodies, enzymes, Fc-fusions, bioconjugated proteins, and protein complexes.
  • Analyze proteins using standard methods (including HPLC, SEC-MALS, CE-SDS, DLS, DSF, MCE and others).
  • Coordinate activities and work collaboratively with colleagues across Discovery and Development to meet timelines and to help advance programs.
  • Think creatively about ways to integrate novel protein modalities with Denali’s BBB-crossing technologies.
  • Actively contribute to project teams and work effectively across functional teams to help advance programs to development.

Successful candidates will meet most of these criteria:

  • PhD in Biochemistry or related scientific discipline with >5 years of experience in biotech/biopharma industry or M.Sc or B.Sc. with ≥8 or ≥12 years of relevant experience, respectively.
  • Extensive knowledge and hands-on experience in the purification and analytical characterization of challenging proteins, complexes and fusion proteins.
  • Extensive programming experience of automated liquid handlers and/or protein purification platforms (FPLC/HPLC/robotics).
  • Excellent oral, presentation and written communication skills are required.
  • Ability to work in a highly dynamic and fast paced environment to contribute to multiple projects.
  • Self-motivated with excellent record keeping and written and verbal communication skills.
  • Creative thinker with a strong sense of responsibility and a desire to collaborate in an exciting and fast-paced research environment.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Salary Range: $142,000.00 to $174,333.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at

*This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

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